Faculty

Irene Guttilla Reed, Ph.D.
Chair and Professor of Biology Joined USJ:B.S., University of New Haven
- E: [email protected]
- P: 860.231.5768
Dr. Reed infuses her courses with her passion for science, and is always looking for ways to incorporate research and critical thinking. With a background in cancer biology, Dr. Reed engages students in independent faculty-mentored research, and also provides course-based research experiences in the classroom. She is also a strong advocate for developing science communication skills, and builds this into all of her courses regardless of the topic. Focused on student-centered learning and engagement, Dr. Reed also participates in outreach programs with local high schools, grant-funded opportunities to provide mentorship and career guidance to students, and advocates for the benefits of undergraduate research at the national level. In 2018, she won the Stack Award for Teaching Excellence and has continued to explore novel pedagogies in the classroom and best practices for inclusive teaching. Her research students have won numerous grants through both USJ and the Tribeta Biological Honors Society and published their research in peer-reviewed scientific journals. Dr. Reed’s research focuses on breast and uterine cancer progression and metastasis, with an emphasis on how changes to the genetic landscape can alter patient prognosis and response to treatment.
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- B.S. in Biology and Forensic Science (2005, University of New Haven)
- Ph.D. in Biomedical Science (2010, UConn Health)
- BIOL114: Introduction to Cellular Biology
- BIOL232: Science Communication
- BIOL250: Introduction to Biological Research
- BIOL350: Advanced Cell Biology
- BIOL300: Current Topics in Biology
- BIOL452: Cancer Biology
- INTD135: Exploration of Careers in the Health Professions
- BIOL519: Cancer Biology (Graduate)
My research with students involves studying the genetic and cell signaling pathways involved in cancer progression. Specifically, we are interested in the molecular mechanisms that promote metastasis (when the disease spreads from the original site to another area in the body), which is responsible for over 90% of cancer-related deaths. Other areas of interest include pedagogical research on best practices for teaching and learning science, integrating research into courses, and promoting critical thinking through writing.
Project 1: Characterizing EMT in breast, endometrial, and pancreatic cancer cells.
- Characterize the expression of various EMT-related genes in breast, endometrial, and pancreatic cancer cell lines.
- Studying the impact of hormones and other chemical compounds (such as flavonoids) on gene expression and cancer growth characteristics.
- Investigate the role of GPR30 signaling in estrogen-responsive endometrial cancer cells via the PI3K signaling pathway and determine the role of GPR30 in regulating downstream EMT-inducing target genes.
Project 2: Examining the role of the novel microRNA signaling pathways in EMT in breast and endometrial cancer.
- The microRNAs that will be examined are hypothesized to be downregulated either in response to EMT and/or may facilitate EMT in various cancer models.
- The functional role of these microRNAs in EMT will be investigated by manipulating levels of these microRNAs and measuring the levels of EMT-related genes, cell growth, and migratory ability.
Project 3: Analyzing cancer genomics and patient outcomes using cBioPortal
- Online cancer genomic databases such as cBioPortal, GeneCards, and UALCAN are used to explore the nature and frequency of mutations in cancer-related genes.
- Relationships between oncogenes and tumor suppressors and their role in cancer initiation and/or metastasis are determined by performing a targeted analysis of genes. Genes are selected based on cancer type, relationships to specific signaling pathways, and/or targeted research questions (such as genes that are involved in metastasis to a particular organ, gender differences between mutations in cancers, etc.).
Project 4: Implementing and assessing novel pedagogies in biology courses
- Projects include the design and development of Course-based Undergraduate Research Projects (CUREs), assessing the impact that writing has on critical thinking and skill development in content-based biology courses, and the development of modules for the Cell Biology Education Consortium (which aims to provide materials to faculty and students to conduct course-based research projects).
I usually supervise 2 – 3 students per semester. There are opportunities for both exploratory (lower-level) and advanced (upper-level) research experiences.
Requirements
- No past research experience required
- An interest in biology, and specifically in cancer biology or gene regulation
- Willingness to write grants to obtain funding for research projects (with my help of course)
Preferred:
- Students interested in doing research for a full academic year (or at least 2 semesters) or more
- Students that are Tribeta members (biological honors society) since it provides additional funding opportunities
Expectations
Commitment to the research process. This includes:
- Actively participating in research on a weekly basis (usually more than one day a week, with an average of 4 – 8 hrs/week)
- Reading and discussing primary literature
- Scheduling times to meet with me (weekly or biweekly) to discuss data, experimental design, and next steps in the project
- Good time management skills (being on time, balancing research with your course workload, etc.)
- Working on grant proposals to obtain funding (both internal at USJ and external)
- Presenting your work in a public forum (i.e. Symposium Day or a local/regional undergraduate research conference) when appropriate (timing to be determined as the project progresses)
Embracing the research process. This includes:
- Being aware that there will be technical and experimental hurdles, but it’s all part of the fun
- Willing to accept suggestions and critique
- Being excited to explore questions we don’t have answers to!
Interview Process
Please contact me via email ([email protected]) to schedule a meeting. We will discuss your interests and expectations as well as mine to see if we have a good fit. Please come prepared with questions since research is a collaborative process! In your email please also indicate if you are interested in beginning research soon (i.e. the next available opening) or if you are just generally inquiring for the future.
Publications
*Ali, S., *Kravitz, M.A., *Rzeszowska M., *Saleh, S. *Gallucci, G.M., and Guttilla Reed, I.K. (2024) GPR30 regulates cell migration and viability and may promote epithelial-mesenchymal transition in endometrial cancer cells. BIOS. (manuscript accepted 8/2/24)
Guttilla Reed, I.K., Kraczkowski, M., and Pearlman, S. (2024) Developing Critical Thinking in Biology Through Progressive Writing Assignments. Journal of College Science Teaching. 1-10. DOI: https://doi.org/10.1080/0047231X.2024.2390298
Guttilla Reed, I.K. (2023) Making research accessible for all through a fully online cancer genomics CURE. Scholarship and Practice of Undergraduate Research. 7(1): 54-59. DOI: https://doi.org/10.18833/spur/7/1/11
Guttilla Reed, I.K. (2020) CUREing cancer: development and implementation of a molecular biology-focused course-based undergraduate research experience using a cancer cell culture model. Biochemistry and Molecular Biology Education. 49(2): 287-297. DOI: https://doi.org/10.1002/bmb.21452
*Anderson O., Guttilla Reed I.K. (2020) Regulation of cell growth and migration by miR-96 and miR-183 in a breast cancer model of epithelial-mesenchymal transition. PLoS ONE 15(5): e0233187. DOI: https://doi.org/10.1371/journal.pone.0233187
Parsons, C., Tayoun, A.M., Benado, B.D., Ragusa, G., Dorvil, R.F., Rourke E.A., O’ Connor, K., Guttilla Reed, I., Alexander, A., Willetts, L., Habibian, M., Adams, B.D. (2018) The role of long noncoding RNAs in cancer metastasis. Journal of Cancer Metastasis and Treatment; 4(19).
DOI: https://doi.org/10.20517/2394-4722.2018.11
*Kent, C.N. and Guttilla Reed, I.K. (2016) Regulation of Epithelial-Mesenchymal Transition in Endometrial Cancer: Connecting PI3K, Estrogen Signaling, and MicroRNAs. Clinical and Translational Oncology; 18(11): 1056-1061. DOI: https://doi.org/10.1007/s12094-016-1492-2
Guttilla Reed, I.K. (2015) Mechanism and Regulation of Epithelial-Mesenchymal Transition in Cancer. Cell Health and Cytoskeleton; 7: 155-166.
DOI: https://doi.org/10.2147/CHC.S73822
Kondaveeti, Y., Guttilla Reed, I.K., and White, B.A. (2015) Epithelial-Mesenchymal Transition Induces Similar Metabolic Alterations in Two Independent Breast Cancer Cell Lines. Cancer Letters; 364(1): 44-58. DOI: https://doi.org/10.1016/j.canlet.2015.04.025
*Slocum, E.M. and Guttilla Reed, I.K. (2015) MicroRNA-100 Targets IGF1R and Regulates Migration in a Breast Cancer Model of Epithelial-Mesenchymal Transition. BIOS; 86(4): 185-192. DOI: https://doi.org/10.1893/0005-3155-86.4.185
Reed, I., Pearlman, S.J., Millard, C. and Carillo, D. (2014) Peer Assessment of Writing and Critical Thinking in STEM: Insights into Student and Faculty Perceptions and Practices. Double Helix; Vol 2.
Presentations
Reed, I.K., Bates, G., Bates, L., Crowder, R. (2023) From Cookbooks to Cell Blocks: Developing a Research-Centered Undergraduate Curriculum, Education Session, American Society for Cell Biology, Boston, MA.
Reed, I.K. (2022) Making CUREs accessible for all: Development and implementation of a fully online cancer genomics CURE. Council on Undergraduate Research ConnectUR National Conference (virtual).
Reed, I.K. (2022) CUREing Cancer: How a virtual cancer genomics CURE made research accessible to students during COVID. Capital PKAL Regional Network Meeting: STEM Instructional Innovations Necessitated by COVID-19: Evolution of Processes Post Pandemic (virtual).
Reed, I.K. (2021) Supporting Underrepresented STEM Majors through Exposure to Research: Successes and Challenges in Year 3 of a S-STEM Grant. Centering Diversity, Equity, and Inclusion in Undergraduate Research and Creative Activity (Council on Undergraduate Research National Conference) (virtual).
Reed, I.K., Dube, D. and Crandall, J. (2020) Supporting underrepresented STEM majors through early advising and student-driven programming (poster presentation). AAC&U Transforming STEM in Higher Education Conference (virtual).
Reed, I.K. and Kraczkowski, M. (2020) No Exams: Using Writing to Promote Critical Thinking in Introductory Biology. C2 Summit for Pedagogical Advancements in STEM (virtual).
Fernandes, J., Frederick, K., Colabry, K. Stith, B., Reed, I.K., Palladino, M., Ryan, J., and Temple-Rosebrook, L. (2020) Planning and Developing a Successful Research Program: A Professional Development Workshop for Postdoctoral Scholars and Graduate Students, Pre-Conference Workshop, Council for Undergraduate Research (CUR) National Conference (virtual).
Reed, I.K. (2019) Invited Speaker: Careers in Academia at Teaching-Focused Institutions. Career Development Program for Graduate Students and Postdoctoral Fellows, American Society for Biochemistry and Molecular Biology, Orlando, FL.
Reed, I.K. (2018) Using an Undergraduate Student Research Project as the Foundation for an Inquiry-based Biology Laboratory Course (poster presentation). Council for Undergraduate Research (CUR) National Conference, Washington D.C.
Reed, I.K. and Kraczkowski M. (2018) Using a Writing Based Mastery Learning Model to Promote Critical Thinking in Introductory Biology (poster presentation). Effective Teaching Strategies in Higher Education Conference, University of New Haven, West Haven, CT
Carillo, D., Reed, I.K., and Cote, J. (2015) Building Interdisciplinarity through Critical Thinking Assessment: A Report from Five Disciplines. National Conference on College Composition and Communication, Tampa, FL.
Reed, I.K., Cote, J., Carillo, D., Pearlman, S.J. (2014) Teaching Scientific Writing and Reasoning using Peer Assessment (poster presentation). National American Society of Microbiology Conference for Undergraduate Educators, Danvers, MA.
Guttilla, I.K. (2013) Teaching Scientific Writing and Reasoning Using Peer Critique and Assessment. Western New England Biology Educators’ Conference, Northwestern Connecticut Community College, Winsted, CT.
- Biology Councilor, Council on Undergraduate Research (CUR)
- Principal Investigator, NSF S-STEM Grant, Award #1742667
- Steering Committee Member, Cell Biology Education Consortium
- Member, American Society of Cell Biology